Finally got around to installing the official Flickr Uploadr on Ubuntu with Wine. The tricky part is that you have to use winetricks to install the MS Visual C++ 2005 runtime dlls, otherwise you get the XULRunner error, "Couldn't load XPCOM."
wget http://h.yimg.com/ce/flickr/FlickrUploadr-3.2/FlickrUploadr-3.2.1-2009.06.02.01-en.exe
chmod +x FlickrUploadr-3.2.1-2009.06.02.01-en.exe
sudo apt-get install wine
wine FlickrUploadr-3.2.1-2009.06.02.01-en.exe
wget http://www.kegel.com/wine/winetricks
sh winetricks vcrun2005
wine "~/.wine/drive_c/Program Files/Flickr Uploadr/Flickr Uploadr.exe"
